Synthesis of aromatic bisabolene natural products via palladium-catalyzed cross-couplings of organozinc reagents.

Cobalt-Catalyzed Cross-Coupling Reactions of Aryl Halides

Transition metal-catalyzed C–C cross-coupling reactions are among the most powerful transformations known to organic chemists, and have received considerable attention over the last decades. For this reason, the development of mild chemo-, regio-, and stereoselective syntheses for the formation of carbon–carbon bonds catalyzed by metal complexes is of great interest. These methods have had a pr...

Nickel-catalyzed Negishi cross-couplings of 6-chloropurines with organozinc halides at room temperature.

An efficient method for the synthesis of 6-alkyl or 6-aryl purines (nucleosides) was developed via nickel-catalyzed Negishi cross-couplings of 6-chloropurines and organozinc halides. The ligand-free process gave good to excellent isolated yields at room temperature.

Palladium-Catalyzed Cross-couplings of Lithium Arylzincates with Aromatic Halides. Synthesis of Analogues of Isomeridianin G and Evaluation as GSK- 3 Inhibitors

Nickel-catalyzed enantioselective cross-couplings of racemic secondary electrophiles that bear an oxygen leaving group.

To date, effective nickel-catalyzed enantioselective cross-couplings of alkyl electrophiles that bear oxygen leaving groups have been limited to reactions of allylic alcohol derivatives with Grignard reagents. In this Communication, we establish that, in the presence of a nickel/pybox catalyst, a variety of racemic propargylic carbonates are suitable partners for asymmetric couplings with organ...

Palladium-catalyzed completely linear-selective Negishi cross-coupling of allylzinc halides with aryl and vinyl electrophiles.

Completely linear: a general and practical palladium-catalyzed linear-selective Negishi coupling of 3,3-disubstituted allylzinc reagents with aryl, heteroaryl and vinyl electrophiles at ambient temperature is described. This method provides an effective means to access a wide range of prenylated arenes or skipped dienes in a completely linear-selective fashion, as demonstrated by a concise synt...